The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials.

نویسندگان

  • Tolulope A Aweda
  • Oluwatayo Ikotun
  • Tara Mastren
  • Carolyn L Cannon
  • Brian Wright
  • Wiley J Youngs
  • Cathy Cutler
  • James Guthrie
  • Suzanne E Lapi
چکیده

Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate of such compounds. Purified 111Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [111Ag]SCC1 and investigated in biodistribution studies.

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عنوان ژورنال:
  • MedChemComm

دوره 4 6  شماره 

صفحات  -

تاریخ انتشار 2013